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Thursday, October 26, 2006

Lack Of Methylglyoxal Causes Cancer...

Getting Methylgyloxal Into Cells Puts The Brakes On Cancer

Dr. Albert Szent-Gyorgyi was the Nobel Laureate in Medicine in 1937 for the isolation and discovery of Vitamin C. Known as the "Father of Nutritional Science", he also discovered iso-flavones and vitamin P. In his last 40 years, he researched the regulatory processes of cell growth, and thereby the regulation of cancer itself.
He made a rather amazing breakthrough about cancer. In 1963 the prestigious magazine "Science" published a remarkable article about his research. In it Dr. Szent-Gyorgyi identified two substances, one called Retine, which inhibited cancer growth, and the other called Promine, which promoted cell growth and made cancerous cells grow faster.
He explained that these were very small molecules that were highly potent in controlling cell division. His research using mice achieved shrinkage of tumors by increasing the ratio of Retine to Promine with daily injections of Retine. Other researchers obtained similar results.
There were no harmful or toxic side effects.
In another "Science" article in 1967 he announced that his laboratory had isolated and manufactured Retine, which retards cell growth, in the form of a Carbonyl compound called Methylglyoxal.
Again, in animal studies he showed that injecting Methylglyoxal daily into mice with cancer was highly effective. The study was divided up into 5 groups of 20 mice each. Every mouse in the control group died in the first 26 - 34 days. All mice were observed for 300 days. The first group began treatment 1 hour after inoculation with cancer. 15 survived
In the second group, beginning treatment 4 hours after inoculation, 13 animals survived. The third group began treatment 24 hours afterwards and 7 survived. The fourth group waited 48 hours and 4 survived.
In an interview in Prevention magazine in 1972 conducted by Jane Kinderlehrer, he explained that he and "Dr. Egyud have found that retine (methylglyoxal) stops the growth of cancer cells without poisoning other cells. When retine is present in sufficient concentration, no cell division can occur while vital cellular processes go on unhindered."
The article goes on, "And what is a good bit of luck, and not my cleverness, the white-haired scientist pointed out, "is that if a cancer cell cannot grow, it dies by itself.' According to the researchers, retine is normally produced by the body and, when it is, it prevents the growth of existing cancer cells. But the body can lose its ability to produce this substance...
"Putting the retine back in the body, just as we put insulin back into a diabetic's body, can stop the growth of cancer... The scientists at Woods Hole found that cancer cells are much more sensitive to retine than normal ones, and so cancer cells may be inhibited specifically."
To sum it up, the Carbonyl group - Glyoxal & Methylglyoxal, are retine. They arrest cell division and make cells return to a resting state. If Carbonyl is missing, uncontrolled proliferation goes on, and cells grow wildly and uncontrollably which leads to cancer. Glyoxal & Methylglyoxal are a non-toxic substance that is supposed to be in your cells. Putting them back in your cells has significant anti-cancer activity.
Another well known Nobel Prize winner of that period, Dr. William Koch, worked on this same issue with a different approach. Dr. Szent-Gyorgyi acknowledged his work saying, "A decade ago, a very intuitive researcher, Dr. William F. Koch, came to the same conclusion about the possible importance of Carbonyls in regulation of cell division and carcinostasis."
Later on in this report I will tell you about more about his work and the products he developed.

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